ARG1 / Arginase 1 Antikörper

14.03.2012

Produkt-Information von ARG1 / Arginase 1 Antikörper

Immunogen	Recombinant Human ARG1 / Arginase 1 protein (Catalog#11558-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human ARG1 / Arginase 1 (rh ARG1 / Arginase 1; Catalog#11558-H08H; P05089-1; Met 1-Lys 322). Total IgG was purified by Protein A affinity chromatography.

ARG1 / Arginase 1 Antikörper Usage Guide

Specificity	Human ARG1 / Arginase 1
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human ARG1 in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human ARG1. The detection limit for Human ARG1 is approximately 0.0049 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von ARG1 / Arginase 1 Antikörper

Arginase-1, also known as Liver-type arginase, Type I arginase and ARG1 is a cytoplasm protein which belongs to thearginase family. Arginase-1 / ARG1 is a manganese-containing enzyme. The reaction catalyzed by this enzyme is: arginine + H2O → ornithine + urea. It is the final enzyme of the urea cycle. Arginase-1 / ARG1 is the fifth and final step in the urea cycle, a series of biophysical reactions in mammals during which the body disposes of harmful ammonia. Specifically, Arginase-1 / ARG1 converts L-arginine into L-ornithine and urea. In most mammals, two isozymes of this enzyme exist; the first, Arginase-1 / ARG1, functions in the urea cycle, and is located primarily in the cytoplasm of the liver. The second isozyme, Arginase-2 / ARG2, has been implicated in the regulation of the arginine/ornithine concentrations in the cell. It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate. Defects in Arginase-1 / ARG1 are the cause of argininemia (ARGIN), also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs.

References

Morris SM et al., 2002, Annual review of nutrition22 (1): 87-105.
Cama E, et al., 2003, Biochemistry42 (28): 8445-51.
Di Costanzo L, et al.,2007,Archives of biochemistry and biophysics 465 (1): 82-9.
Van de Poll,M.C. et al., 2008, Clin Sci. 114 (3): 231-41.
Haffner,I. et al., 2008,J Cell Biochem. 103 (2): 520-7.

Sino Biological Inc. liefert ARG1 / Arginase 1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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