APOM Protein

29.03.2012

APOM Protein Product Information

Synonym	DADB-127H9.5, G3a, HSPC336, NG20
Protein Construction	A DNA sequence encoding the human APOM (O95445) (Met 1- Asn 188) was fused with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von APOM Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: APOM protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 23
Molecular Mass	The recombinant human APOM/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 407 amino acids and has a predicted molecular mass of 45.6 kDa. The apparent molecular mass of the reduced monomer is approximately 50 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

APOM Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von APOM Protein

APOM(apolipoprotein M,human IgG1-Fc chimera) is an apolipoprotein and member of the lipocalin protein family. Lipocalins have been associated with many biological processes, among them immune response, pheromone transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. APOM is highly divergent. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized. APOM can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.

References

Xu N. et al., 1999, J Biol Chem. 274 (44): 31286-90.
Duan J. et al., 2001, FEBS Lett. 49 (1-2): 127-32.
Albertella MR. et al., 1997, Genomics. 36 (2): 240-51.

Sino Biological Inc. liefert APOM Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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