ADAM15 Antikörper ( FITC )

Sino Biological Inc. liefert ADAM15 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ADAM15 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/ADAM15-Antibody-g-10064.html

Produkt-Information von ADAM15 Antikörper

Usage Guide von ADAM15 Antikörper

Specificity	Human ADAM15
Flow Cytometry	Profile of anti-ADAM15 reactivity on HeLa cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von ADAM15 Antikörper

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>ADAM / ADAMTS>>ADAM15

Cancer>>Angiogenesis>>ADAM / ADAMTS>>ADAM15

Hintergrund von ADAM15 Antikörper

The adamalysin (ADAM) metalloproteinase disintegrins, also known as metalloprotease/disintegrin/cysteine-rich proteins, are a branch of the metzincin metalloproteinase superfamily that are related to snake venom metalloproteinases and integrin ligands. Human ADAM15 was first named metargidin, and uniquely, it carries an RGD binding motif in a position similar to that in snake venom disintegrins. ADAM15 is widely expressed in various tissues and cells, including human umbilical vein endothelial cells and smooth muscle cells, and its expression can be drived by Vascular endothelial (VE)-cadherin. Overexpression of ADAM15 in NIH3T3 cells appears to enhance cell-cell interactions, as suggested by decreased cell migration, altered cell morphology at the wound edge, decreased monolayer permeability, and increased cell adhesion to monolayers of cells expressing ADAM15 by retroviral transduction. ADAM15 plays a physiological roleas a natural binding partner of integrin αvβ3 thereby loosening tumor cell adhesion to the underlying matrix and regulating tumor cell migration and invasion, and functional interplay between ADAM15 and Src family PTKs may contribute to signaling in hematopoietic cells. Aslo, ADAM15 is believed to interact with integrins αvβ3, α5β1, and α9β1 through its disintegrin domain. ADAM15 has been shown to degrade collagens I and IV and to cleave the inflammatory cytokine CD23, thus influence ECM remodeling within rheumatoid synovial tissues and in atherosclerosis.The high expression levels of ADAM15 correlated with advanced metastatic diseases, and a clear association with clinical parameters was determined.

References

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7. Xi-Ping Zhang, et al., 1998, THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273, No. 13: 7345-7350.
8. Rainer Kuefer, et al., 2006, Neoplasia. Vol. 8, No. 4: 319-329.

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