ACE2 Antikörper

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Proteine:

Antikörper:

Angiotensin-converting enzyme 2, also known as ACE-related carboxypeptidase, Angiotensin-converting enzyme homolog, Metalloprotease MPROT15, ACEH and ACE2, is a single-pass type I membrane protein which belongs to thepeptidase M2 family. ACEH / ACE2 is identified as a zinc metalloprotease structurally consisting of a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACEH / ACE2 is expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. It is expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). It is expressed in heart, kidney, testis, and gastrointestinal system. ACEH / ACE2 is a carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. It is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACEH / ACE2 may be an important regulator of heart function. It may also serve as functional receptor for the spike glycoprotein of both coronaviruses.

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